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Submitted: 25 Jan 2016
Revision: 19 Feb 2016
Accepted: 22 Feb 2016
ePublished: 14 Mar 2016
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Avicenna J Clin Microbiol Infect. 2017;4(1): 36646.
doi: 10.17795/ajcmi-36646
  Abstract View: 954
  PDF Download: 567

Research Article

Antimicrobial Effects of Ferula persica Gum Extract and Gold Nanoparticles on Pseudomonas aeruginosa

Bahareh Nasrollahi Nejad 1, Zahra Bamzadeh 1, Seyed Hossein Hejazi 2*

1 Biology Department, Basic Sciences Faculty, Shahrekord Branch, Islamic Azad University, Shahrekord, IR Iran
2 Skin Disease and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
*Corresponding Author: Corresponding author: Seyed Hossein Hejazi, Skin Disease and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran, Email: hejazi@med.mui.ac.ir

Abstract

Background: In the treatment of bacterial infections, drug resistance is a global problem; Pseudomonas aeruginosa is no exception. This bacterium is among the important causes of nosocomial infections, especially burn wound infections, and it is resistant to most applicable antibiotics.

Objectives: The present study aimed to evaluate the anti-bacterial effects of Ferula persica gum extract and gold nanoparticles on P. aeruginosa strains isolated from burn wound infections in Isfahan in 2012.

Materials and Methods: In this experimental study, 150 P. aeruginosa strains carrying the blaSPM-1 gene were isolated from burn wound infections and were confirmed by biochemical tests. The anti-microbial activities of Ferula persica gum extract and gold nanoparticles were evaluated by agar well-diffusion assay and microdilution antimicrobial susceptibility tests. The results were compared to ciprofloxacin.

Results: The highest mean zone of inhibition (18 mm) was observed in a concentration of 250 mg/mL of F. persica extract, which was equal to that of ciprofloxacin. In the gold nanoparticles, the highest mean growth inhibition zone (10.18 mm) was observed in the dilution of 50 ppm. The highest zone of inhibition of nanoparticle-extract synergy was observed in the dilution of 125 mg/mL extract + 25 ppm nanoparticle (9.89 mm). The MIC and MBC of the extract were 69.25 ± 42.36 mg/mL and 102.25 ± 16.76 mg/mL, respectively. The MIC and MBC of the nanoparticle-extract mixture were 50.78 ± 19.26 mg/mL and 54.11 ± 19.72 mg/mL, respectively.

Conclusions: The results of the present study showed that the extract of F. persica gum and the gold nanoparticles had antiPseudomonas aeruginosa effects, which were more pronounced when they were used separately. 


Copyright © 2016, Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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