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Submitted: 15 May 2024
Revision: 20 Jun 2024
Accepted: 22 Jun 2024
ePublished: 30 Jun 2024
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Avicenna J Clin Microbiol Infect. 2024;11(2): 82-86.
doi: 10.34172/ajcmi.3550
  Abstract View: 162
  PDF Download: 65

Original Article

A Study of Antimicrobial Resistance Rates in Clinical Burn Center Isolates of Pseudomonas aeruginosa in the South of Iran

Elham Jafarzadeh 1 ORCID logo, Masoud Kargar 2,3,4* ORCID logo, Susan Amiri 5

1 Department of Laboratory Sciences, Taleghani Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Medical Laboratory Sciences, School of Allied Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Department of Biotechnology, Azad University, Ahvaz, Iran
*Corresponding Author: Masoud Kargar, Email: Masoudkargar17@gmail.com

Abstract

Background: This research aimed to examine the frequency of resistance to antimicrobial agents and their variations in Pseudomonas aeruginosa clinical isolates, which are accountable for invasive infections in the southern part of Iran, from 2018 to 2022.

Methods: A retrospective study was conducted, involving the gathering of microbiological data from Taleghani Burn Hospital from 2018 to 2022. The primary variables under scrutiny were department, sample origin, the antiprogram system (e.g., disc diffusion and strip methods, and clinical laboratory standards), and the rate or percentage of resistant isolates investigated by antimicrobial susceptibility testing. The interpretation criteria employed for the study were those of the Clinical Laboratory Standards Institute (CLSI). And the percentage of resistant isolates was also taken into consideration.

Results: The disc diffusion and strip method is the most commonly used approach for antimicrobial susceptibility testing. According to the CLSI, resistance rates ranged from 3.64% (colistin) to 77.38% (amikacin). The rates of antimicrobial resistance remained relatively constant over time in 2018-2022. Approximately 67.62% of isolates were multidrug resistant, and the remaining 9.46% were extensively drug-resistant. Wound and urine isolates demonstrated higher resistance, except for amikacin and piperacillin, than those from blood culture and biopsy.

Conclusion: Antimicrobial resistance is widely prevalent in P. aeruginosa, a common bacterium in southern Iran. The findings revealed the highest resistance rates for commonly used antibiotics such as amikacin, piperacillin, ceftazidime, and meropenem. However, colistin and nitrofurantoin are more effective against this bacterium. The wound and urine isolates represented the highest resistance rates, indicating the need for prompt and appropriate treatment. Interestingly, the resistance rates for most antibiotics remained relatively stable during the study period, emphasizing the need to develop alternative treatments for P. aeruginosa infections.


Please cite this article as follows: Jafarzadeh E, Kargar M, Amiri S. A study of antimicrobial resistance rates in clinical burn center isolates of pseudomonas aeruginosa in the south of Iran. Avicenna J Clin Microbiol Infect. 2024; 11(2):82-86. doi:10.34172/ajcmi.3550
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