Submitted: 14 Sep 2020
Accepted: 24 May 2021
ePublished: 29 Sep 2021
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Avicenna J Clin Microbiol Infect. 2021;8(3): 94-97.
doi: 10.34172/ajcmi.2021.17
  Abstract View: 374
  PDF Download: 223

Original Article

Antibacterial Activity of New Compounds Based on Nanocomposites

Maryam Kouhkan 1 ORCID logo, Fatemeh Ghanbary 2* ORCID logo, Fatemeh Karimi 3

1 Young Researchers and Elite Club, Urmia Branch, Islamic Azad university, Urmia, Iran
2 Department of Chemistry, Mahabad Branch, Islamic Azad university, Mahabad, Iran
3 Department of veterinary,Urmia Branch, Islamic Azad University, Urmia,Iran
*Corresponding Author: *Corresponding author: Fatemeh Ghanbary, Department of Chemistry, Mahabad Branch, Islamic Azad university, Mahabad, Iran, Email: , Email: Ghanbary83@yahoo. com


Background: Antimicrobial resistance is a major problem in treatment and public health, and it has been increasing over the last few decades. Hence, serious measurements are needed to overcome this challenge. In this study, we evaluated antibacterial and antifungal activity of some nanocomposites including titanium dioxide (5a), polyimide nanocomposites containing cerium oxide (5b), silver-titanium dioxide nanoparticles prepared under desired conditions (5c), polyaniline/wheat husk ash PANI /WHA (5d), Ag-TiO2 prepared by sol–gel route (5e), and cellulose-graphene (5f) against some bacterial and fungal strains, which are the most common agents in many infectious diseases.

Methods: The nanoparticles were prepared in desired condition. The agar dilution and well agar diffusion methods were used for determination of inhibition zoon and minimum inhibitory concentration (MIC) during preliminary evaluation of antimicrobial activity against Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Escherichia coli and Candida albicans.

Results: The results showed that the nanocomposites had good activity against gram-negative bacteria.

Conclusions: Our results showed that the inhibitory activity of these nanocomposites on gram-negative bacteria was better than gram-positive bacteria.

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