Submitted: 15 Aug 2020
Accepted: 12 Oct 2020
ePublished: 29 Sep 2021
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Avicenna J Clin Microbiol Infect. 2021;8(3): 108-112.
doi: 10.34172/ajcmi.2021.20
  Abstract View: 564
  PDF Download: 192

Original Article

Epidemiological Distribution and Potential Risk Factors of Orientia tsutsugamushi Infection in Eastern Uttar Pradesh, India

Alka Shukla 1, Mayank Gangwar 1, Akanksha Srivastava 1, Sonam Rastogi 1, Deepak Kumar 1, Digvijay Singh 1, Rajesh Kumar 1, Pradyot Prakash 1, Gopal Nath 1* ORCID logo

1 Viral Research and Diagnostic Laboratory, Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
*Corresponding Author: *Corresponding author: Gopal Nath, Viral Research and Diagnostic Laboratory, Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India Fax: +91-542-2367568, Tel: +91-542-2309506, +91-542-2316420, M: +91-9335058394, Email: , Email: gopalnath@gmail.com


Background: Scrub typhus (ST) is a rickettsial infection caused by Orientia tsutsugamushi, which presents with flu like symptoms. This disease has been reported from all over India but with slight variations in its pattern. For decreasing the prevalence, preventing new incidences, and predicting the course of the ST, therefore, it is crucial to gain knowledge and perception of local risk components associated with the disease. The present study aimed to investigate the epidemiological distribution and potential risk factors of O. tsutsugamushi Infection in Eastern Uttar Pradesh (EUP), India.

Methods: The serums of 211 samples were collected from the suspected cases along with the detailed information about the participants such as age, location, and place recorded in case history form (CRF). IgM estimation was performed using enzyme-linked immunosorbent assay (ELISA) assay.

Results: A total of 58 samples (27.4%) out of 211 ones were found to be positive for IgM antibodies against O. tsutsugamushi bacterium. Furthermore, the results were correlated with epidemiological data such as gender, rural or urban background, pets, and occupation. The results showed that 76.7% of the study participants were from rural areas or had bushes around their houses, 88.3% of them had pets/cattle or frequent encounter with rodents at their houses, and 30.3% of them had no toilet facilities at home.

Conclusions: It was concluded that the proximity to pets/cattle, having rodents in closer vicinity, residing in places surrounded by vegetation/farm/bushy areas, and following occupations involving field work increased the chances of getting bitten by mites/chiggers. Overall, Orientia tsutsugamushi prevalence increased in EUP, with respect to clinical features, disease presentation, and laboratory diagnosis can help our community to reduce the mortality caused by this infectious disease.

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