Hamadan University of Medical Sciences Avicenna Journal of Clinical Microbiology and Infection 2383-0298 9 2 2022 06 29 MicroRNA155 May Be an Important Part of Human Papilloma Virus-Related Cancers 77 80 10.34172/ajcmi.2022.12 EN Banafsheh Douzandeh-Mobarrez https://orcid.org/0000-0002-1452-1881 Ashraf Kariminik https://orcid.org/0000-0001-6489-9500 Babak Kheirkhah https://orcid.org/0000-0003-2110-7715 Journal Article 10.34172/ajcmi.2022.12 2022 03 01 2022 04 20 Background: Micro-RNAs (miRs) play several roles during infections with viruses. Therefore, the roles of miR21 and mir155 in the induction of the viral-related cancers have been the focus of attention in several studies. High risk human papilloma viruses (HPVs) are the main factors negatively contributing to the induction of HPV-related cancers. This study aimed to evaluate the expression of miR21 and mir155 in the patients with HPV-high risk genotypes in order to explore the roles of the miRs in the induction of HPV-related cancers. Methods: In this study, 40 women infected with the high-risk HPV genotypes as well as 40 healthy controls were examined regarding the relative expression of miR21 and mir155 by adopting real-time polymerase chain reaction (PCR) technique. U6 was used for data normalization of miRNAs. Results: Relative expressions of both miR21 and miR155 were significantly higher in the HPV-infected patients compared to those in non-infected women. Conclusions: It was concluded that miR21 and miR155 may have played key roles in the induction of HPV-related cancers among Iranian patients.