Hamadan University of Medical Sciences Avicenna Journal of Clinical Microbiology and Infection 2383-0298 6 1 2019 02 01 Does AUC/MIC Ratio Predict Efficacy and Safety of Vancomycin? 31 42 10.34172/ajcmi.2019.07 EN Omid Arasteh https://orcid.org/0000-0002-8905-1781 Hossein Khalili https://orcid.org/0000-0002-8905-1781 REVIEW 10.34172/ajcmi.2019.07 2019 01 10 2019 02 20 In this review, the studies in which potential correlation between the area under the curve/minimum inhibitory concentration ratio of vancomycin (AUC/MIC) and its efficacy and safety had been considered, were assessed. Papers that had defined the potential correlation between vancomycin AUC/MIC and its efficacy, safety, or both as a primary outcome were included. Considering that extent of vancomycin exposure as well as susceptibility of microorganisms were both included, AUC/MIC seemed to be a more accurate index than serum trough concentration for predicting vancomycin efficacy. However, data regarding correlation between this index and vancomycin-induced nephrotoxicity are limited. Different breakpoints have been defined for AUC/MIC. The optimized use of vancomycin can improve its efficacy and defer the occurrence of tolerance. Further studies are needed to define optimum vancomycin AUC/MIC breakpoints and in turn predict its efficacy and safety.