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Submitted: 30 Nov 2015
Revision: 28 Jan 2016
Accepted: 04 Feb 2016
ePublished: 26 May 2016
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Avicenna J Clin Microbiol Infect. 2016;3(2): 35148.
doi: 10.17795/ajcmi-35148
  Abstract View: 879
  PDF Download: 483

Research Article

The Pro115Gln Missense Mutation of Peroxisome Proliferator Activated Receptor γ (PPARγ) Gene in Diabetes in the Pakistani Population

Sarwar Sumbal 1, Shabana . 1*

1 Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan
*Corresponding Author: Corresponding author: Shabana, Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan. Tel: +92-3324327547, Fax: +92-4235952855, Email: shabana.mmg@pu.edu.pk

Abstract

Background: Diabetes is an alarmingly increasing public health concern. According to a World Health Organization (WHO) report, diabetes is highly prevalent in almost all regions of Pakistan, with an overall prevalence of 22.04% in urban and 17.15% in rural areas. In addition to lifestyle factors, genetics plays an important part in the progression to diabetes, of which peroxisome proliferator activated receptors (PPARs), a super-family of transcriptional regulators, are considered to be very critical.

Objectives: The aim of the current study was to investigate the prevalence of a missense mutation Pro115Gln in the PPARγ; gene in Pakistan and search for its effects on certain serum biochemical parameters.

Materials and Methods: A total of 1015 subjects (490 diabetics and 525 healthy controls) were genotyped by PCR-RFLP and serum profiling was performed.

Results: We could not detect the mutation in the study subjects, but the anthropometric and biochemical parameters were significantly different between the cases and controls.

Conclusions: In conclusion, as this mutation is present in a highly conserved region and any change in this region would adversely affect the protein structure and function, so the prevalence of this mutation is very low. 


Copyright © 2016, Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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