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Submitted: 13 Jun 2015
Revision: 07 Nov 2015
Accepted: 15 Nov 2015
ePublished: 23 Jan 2016
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Avicenna J Clin Microbiol Infect. 2016;3(1): 29989.
doi: 10.17795/ajcmi-29989
  Abstract View: 1159
  PDF Download: 442

Brief Report

Risk Factors Associated With Imipenem-Resistance Among Isolated Gram -Negative Bacteria From Patients in Sanandaj Hospitals, Iran

Behzad Mohsenpour 1, Samaneh Rouhi 1,2,3, Roghaye Mehrdel 2, Tayyebe Faraji 2, Milad Masaeli 2, Rashid Ramazanzadeh 1,3*

1 Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, IR Iran
2 Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, IR Iran
3 Department of Microbiology, Kurdistan University of Medical Sciences, Sanandaj, IR Iran
*Corresponding Author: Corresponding author: Rashid Ramazanzadeh, Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, IR Iran. Tel: +98-9143104424, Fax: +98-8716664674,, Email: atrop_t51@yahoo.com

Abstract

Background: The use of imipenem antibiotics against Gram-negative bacteria is growing, but the incidence of imipenem-resistant bacteria is also increasing.

Objectives: The aim of this study was to determine the risk factors for imipenem resistance in patients with Gram-negative bacteria infections.

Patients and Methods: An imipenem minimum inhibitory concentrations (MIC) test was done using the E-test, and a survey of different risk factors of imipenem resistance in 374 patients who were infected solely by Gram-negative bacteria was performed.

Results: Of the 374 isolated, 134 were imipenem resistant, and 240 were sensitive to imipenem. The resistance rate was more common in males and in patients with intensive care unit (ICU) admission, trauma-induced infections, a history of antibiotic use, the need for ventilator support, or central venous catheter insertion, and in nosocomial infections.

Conclusions: Our results showed the rate of effects of different risk factors on imipenem resistance. Regarding the studied risk factors, appropriate programs must be set in place to control and prevent imipenem resistance in Gram-negative bacteria.


Copyright © 2016, Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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