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Submitted: 21 Jul 2022
Revision: 20 Sep 2022
Accepted: 03 Oct 2022
ePublished: 22 Oct 2022
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Avicenna J Clin Microbiol Infect. 2022;9: 115-118.
doi: 10.34172/ajcmi.2022.3399
  Abstract View: 16
  PDF Download: 18

Original Article

Royal Jelly Feeding as a Main Inducer of Bcl-2-associated X Protein in the Peripheral Blood Immune Cells of Patients With Chronic Hepatitis B

Morteza Bahaaldin-Beygi 1 ORCID logo, Ashraf Kariminik 1* ORCID logo, Mohammad Kazemi Arababadi 2,3 ORCID logo

1 Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran
2 Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3 Department of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
*Corresponding Author: Corresponding author: Ashraf Kariminik, Email: , Email: a.kariminik@iauk.ac.ir

Abstract

Aim: Chemokines, cytokines, and their related molecules play crucial roles in the fight against the hepatitis B virus (HBV) and its related complications. Royal jelly (RJ) is considered an immunomodulatory factor for humans. This clinical trial study aimed to explore the RJ effects on the relative expression of CCL2, CCL3, CCL8, IFN-β, NANOG, OCT4, BAX, and MAVS in chronic hepatitis B (CHB) patients.

Methods: The CHB patients were under one month of RJ treatment, 1 g/d. The relative expressions of CCL2, CCL3, CCL8, IFN-β, NANOG, OCT4, BAX, and MAVS were evaluated using the real-time polymerase chain reaction (PCR) technique.

Results: RJ feeding significantly increased the expression of BAX in the peripheral blood immune cells of CHB patients. However, relative expressions of CCL2, CCL3, CCL8, IFN-β, NANOG, OCT4, and MAVS were not altered following RJ feeding.

Conclusion: RJ can modulate immune responses via induction of homeostasis in the peripheral blood immune cells of CHB patients. Reduced inflammation following RJ feeding may be a result of homeostasis in the peripheral blood immune cells.

Keywords: Chronic hepatitis B, Royal jelly, Chemokine, Gene expression

Please cite this article as follows: Bahaaldin-Beygi M, Kariminik A, Kazemi Arababadi M. Royal jelly feeding as a main inducer of bcl2-associated x protein in the peripheral blood immune cells of patients with chronic hepatitis b. Avicenna J Clin Microbiol Infect. 2022; 9(3):115-118. doi:10.34172/ajcmi.2022.3399
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