Submitted: 20 Aug 2014
Revision: 10 Sep 2014
Accepted: 16 Sep 2014
ePublished: 19 Oct 2014
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Avicenna J Clin Microbiol Infect. 2014;1(3): 22934.
doi: 10.17795/ajcmi-22934
  Abstract View: 682
  PDF Download: 331

Research Article

Prevalence of Extended Spectrum β-Lactamase in Klebsiella pneumonia Isolates in a Teaching Hospital of Zahedan City, Iran

Mahbobeh Barakzahi 1, Bahman Hormozi 1, Ahmad Rashki 2*, Zahra Rashki Ghalehnoo 3

1 Department of Biology, Faculty of Basic Sciences, University of Zabol, Zabol, IR Iran
2 Department of Physiopathology, Faculty of Veterinary Medicine, University of Zabol, Zabol, IR Iran
3 Departments of Microbiology and Parasitology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, IR Iran
*Corresponding Author: Corresponding author: Ahmad Rashki, Department of Physiopathology, Faculty of Veterinary Medicine, University of Zabol, Zabol, IR Iran. Tel: +98-9151970877, Fax: +98-5422240735, Email: ah_rashki@usal.es


Background: Extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumonia has become widespread in hospitals and is increasing in community settings. Most of K. pneumonia that harbor these enzymes, display resistance to other unrelated antimicrobial agents and thus, often pose a therapeutic dilemma.

Objectives: This study was conducted to determine the prevalence of ESBL-producing K. pneumonia in a major university hospital in Zahedan, Iran.

Materials and Methods: The susceptibility of 83 K. pneumonia isolates to 12 antibiotics was assessed using Kirby-Bauer disc diffusion method. For the ESBL phenotypic test, double-disk diffusion (DD) method was used.

Results: The highest resistance rates of the isolates were seen against cefixime (82%), cefotaxime (81%), ceftriaxone (73%), ceftazidime (72%), and azithromycin (60%), consecutively. The lowest resistance rates were observed against gentamicin (58%), tetracycline (59%), nalidixic acid (59%), and amikacin (63%), consecutively. ESBLs were found in 65% of K. pneumonia isolates.

Conclusions: We found that 65% of K. pneumonia isolates produced ESBL. Therapeutic strategies to control infections should be carefully formulated in teaching hospitals. The high percentage of drug resistance in ESBL-producing K. pneumonia suggests that routine detection of ESBL by reliable laboratory methods is required.

Copyright © 2014, Hamadan University of Medical Sciences; Published by Safnek. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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