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Submitted: 10 Jun 2014
Revision: 20 Jun 2014
Accepted: 30 Jun 2014
ePublished: 01 Aug 2014
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Avicenna J Clin Microbiol Infect. 2014;1(2): 21622.
doi: 10.17795/ajcmi-21622
  Abstract View: 2026
  PDF Download: 1145

Research Article

Nosocomial Candiduria in Critically Ill Patients Admitted to Intensive Care Units in Qazvin, Iran

Seyed Amir Ghiasian 1,4*, Mohammad Reza Aghamirian 2, Golam Reza Eshghi 3,4

1 Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
2 Department of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
3 Department of Dermatology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
4 Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
*Corresponding Author: Corresponding author: Seyed Amir Ghiasian, Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran. Tel: +98-9188129953, Email: s.a.ghiasian@umsha.ac.ir

Abstract

Background: A broad variety of fungi, especially Candida species, are becoming increasingly common causes of urinary tract infections in hospital settings.

Objectives: The current cross-sectional descriptive study aimed to determine the causative agents, risk factors and incidence rate of candiduria in critically ill patients, hospitalized in intensive care units (ICUs) of four Iranian hospitals.

Patients and Methods: A total of 155 children and adult patients, admitted to ICUs of the four university educational hospitals, who demonstrated Candida-positive urine cultures, were examined. Samples were processed via mycological procedures by direct microscopy and culture.

Results: Candiduria was confirmed in 50 (32.26 %) patients and Candida albicans was the most frequently isolated species representing 60.0% of isolates, followed by 14.0% C. glabrata, 12.0% C. parapsilosis, 10.0% C. krusei, and 4.0% C. tropicalis. Most patients were female (58%) with a mean age of 46.7 years old. Generally, 39.7% and 62% of adults and children showed candiduria, respectively. The commonest predisposing factors were antibiotic therapy (98.0%), urinary catheterization (92.0%), corticotherapy (84.0%), being female (42.6 %), use of feeding tube (56%), and extended hospitalization, respectively.

Conclusions: The high frequency of candiduria in ICU patients can be decreased by shortening the duration of urinary catheterization, avoiding extra antibiotics and corticosteroids, as well as controlling the predisposing factors and underlying conditions.


Copyright © 2014, Hamadan University of Medical Sciences; Published by Safnek. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 
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