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Submitted: 05 May 2024
Revision: 04 Jun 2024
Accepted: 17 Jun 2024
ePublished: 30 Jun 2024
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Avicenna J Clin Microbiol Infect. 2024;11(2): 68-73.
doi: 10.34172/ajcmi.3545
  Abstract View: 192
  PDF Download: 101

Original Article

Effects of Oral Probiotic Supplements on the Rate of Vaginal Colonization of Group B Streptococcus in Pregnant Women: A Clinical Trial Study

Kiana Shirani 1 ORCID logo, Behrooz Ataei 1 ORCID logo, Elahe Zarean 2 ORCID logo, Soodabeh Rostami 3 ORCID logo, Ashkan Mortazavi 4 ORCID logo, Elham Tooti 5 ORCID logo, Alireza Assadi 4* ORCID logo

1 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Infectious Disease, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Alireza Assadi, Email: alirezaassadi76@gmail.com

Abstract

Background: Management of Group B Streptococcus (GBS) infection in a pregnant woman is one of the serious challenges for gynecologists and infectious disease specialists. The present clinical trial study aimed to investigate the impact of oral probiotic supplements on the rate of vaginal colonization of GBS in pregnant women.

Methods: Overall, 64 pregnant patients with vaginal GBS were selected to participate in this study. They were randomly divided into two groups (n=32/each). The intervention group received a probiotic supplement capsule at a dose of 500 mg daily for 30 days, and the control group received a placebo for 30 days. At the end of the study on day 30, the vaginal sample was retaken with a sterile swab, and all the steps performed at the beginning of the study to diagnose GBS were repeated.

Results: The average mean gestation at the first vaginal sampling was 27.09±2.48 weeks. There was no meaningful difference in age between the two groups of patients (P=0.47). Moreover, no considerable difference was found in the body mass index (P=0.37), weeks of gestation (P=0.92), or number of pregnancies (P=0.89) between the two groups. A significant relationship was observed between positive GBS and BMI in pregnant women (P=0.001), but this meaningful relationship was not found between GBS and age of patients (P=0.86) and age of pregnancy (P=0.16). Finally, there was no significant difference between the probiotic and placebo groups in terms of secondary test results for GBS (P=0.07).

Conclusion: In the present study, oral probiotic supplementation did not significantly alter GBS in pregnant women, but for a definite opinion, a study with a larger sample size, different vaginal sampling techniques, a higher dose of oral probiotics, and an increase in the length of the intervention period is essential.


Please cite this article as follows: Shirani K, Ataei B, Zarean E, Rostami S, Mortazavi A, Tooti E, et al. Effects of oral probiotic supplements on the rate of vaginal colonization of group b Streptococcus in pregnant women: a clinical trial study. Avicenna J Clin Microbiol Infect. 2024; 11(2):68-73. doi:10.34172/ajcmi.3545
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