Submitted: 30 Apr 2023
Revision: 27 Sep 2023
Accepted: 24 Dec 2023
ePublished: 29 Dec 2023
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Avicenna J Clin Microbiol Infect. 2023;10(4): 157-161.
doi: 10.34172/ajcmi.3455
  Abstract View: 476
  PDF Download: 247

Original Article

In Vitro Evaluation of the Effects of Pelargonium quercetorum Agnew Extracts on Trichomonas vaginalis

Ali Azimi Kohan 1 ORCID logo, Dara Dastan 2,3 ORCID logo, Mohammad Fallah 1 ORCID logo, Mohammad Matini 1* ORCID logo

1 Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2 Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Mohammad Matini, Email: matini@umsha.ac.ir, Email: matini.mohammad@yahoo.com


Background: Trichomonas infection is a common sexually transmitted infection, and concerns about drug resistance to this infection are increasing. The aim of this study was to evaluate the in vitro activity of Pelargonium quercetorum extracts on Trichomonas protozoans.

Methods: One isolate of Trichomonas vaginalis was subjected to susceptibility testing against ethyl acetate, n-hexane, and aqueous extracts of P. quercetorum using the microtiter plate method. The minimum lethal concentration (MLC) of the extracts was measured in comparison with metronidazole under aerobic conditions.

Results: All extracts had antiprotozoal activities against Trichomonas. After 48-hour exposure, the most antitrichomonal activity of the extracts belonged to the ethyl acetate, with an MLC of 250 µg/mL, followed by the n-hexane (500 µg/mL) and aqueous (25 mg/mL) extracts in comparison with metronidazole, with an MLC of 3.1 µg/mL.

Conclusion: The results of this study indicated that P. quercetorum has potential properties against Trichomonas protozoans, although further studies are needed to evaluate the antiprotozoal activity of its components.

Please cite this article as follows: Azimi Kohan A, Dastan D, Fallah M, Matini M. In Vitro evaluation of the effects of Pelargonium quercetorum agnew extracts on Trichomonas vaginalis. Avicenna J Clin Microbiol Infect. 2023; 10(4):157-161. doi:10.34172/ajcmi.3455
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