Submitted: 31 Aug 2020
Accepted: 01 Oct 2020
ePublished: 30 Mar 2021
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Avicenna J Clin Microbiol Infect. 2021;8(1): 5-10.
doi: 10.34172/ajcmi.2021.02
  Abstract View: 297
  PDF Download: 89

Original Article

Synthesis and Characterization of Chemical Compounds Derived From Benzohydrazide and Evaluation of Their Antibacterial Activities

Maryam Alizadeh 1, Ashraf Kariminik 1* ORCID logo, Ali Akbari 2

1 Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran
2 Department of Chemistry, Faculty of Science, University of Jiroft, Jiroft, Iran
*Corresponding author: Ashraf Kariminik, Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran. Email: a.kariminik@iauk.ac.ir


Background: The antimicrobial resistance of pathogenic bacteria has emerged as a major health problem in recent years. Extensive research has been conducted to find new antimicrobial agents.

Objectives: The aim of this study was to examine the antibacterial activities of benzohydrazide derivatives.

Methods: Manganese hydrogen sulfate choline chloride was applied in a simple method for synthesizing benzohydrazide derivatives. Antibacterial activities of the derivatives were assessed against Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Bacillus subtilis, diphtheroids, Salmonella enterica, Serratia marcescens, Pseudomonas aeruginosa, and Klebsiella pneumoniae. The structure of the synthesized compounds was determined employing 1 H/13C NMR and Fourier-transform infrared (FT-IR) spectroscopy. The reactions were carried out in choline chloride dissolved in water at room temperature.

Results: The results of this study showed that benzohydrazide derivatives had very desired antibacterial activities against the assessed bacteria.

Conclusions: Further investigations are required to assess the safety and efficacy of benzohydrazide derivatives as antibacterial agents in vivo and in vitro.

Keywords: Antibacterial activity, Benzohydrazide derivatives, Pathogenic bacteria
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