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Submitted: 27 Jul 2014
Revised: 26 Aug 2014
Accepted: 21 Sep 2014
First published online: 12 Oct 2014
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Avicenna J Clin Microbiol Infect. 2014;1(3): e22343.
doi: 10.17795/ajcmi-22343
  Abstract View: 461
  PDF Download: 204

Research Article

Seroprevalence of Hepatitis E Virus Among Injection Drug Users and Non-Injection Drug Users in Hamadan, West of Iran 

Fariba Keramat 1, Mojgan Mamani 1 * , Mahdi Samadi 2, Somaieh Mohammadnezhad 3, Peyman Eini 1, Abbas Moradi 4

1 Brucellosis Research Center, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, IR Iran
2 Department of Psychology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, IR Iran
3 School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
4 Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
Corresponding author: Mojgan Mamani, Brucellosis Research Center, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, IR Iran. Tel: +98-9183156757, Fax: +98- 8138269808 Email: mamanimojgan@yahoo.com

Abstract

Background: Hepatitis E virus (HEV) infection is a self-limited hepatitis and the most common cause of acute adult hepatitis in Asia. Young adults and middle-aged populations are more likely to be infected than other age groups.

Objectives: The aim of this study was to determine the seroprevalence of anti-HEV among injection drug users (IDUs) compared to nonIDUs.

Patients and Methods: This was a cross-sectional study performed on 131 IDUs referred to Farshchian Hospital, Hamadan, Iran and 131 nonIDUs selected from healthy visitors between March 2011 and March 2012. Anti-HEV IgG was measured in serum by ELISA method (DiaPro, Milan, Italy). Data including age, gender, education, location and duration of injection drug used were collected using a questionnaire.

Results: In this study, the seroprevalence of hepatitis E virus antibody among IDUs group was 6.1%, and 1.5% among non-IDU group (Odds Ratio = 5.48; CI = 1/069-22/84), indicating that injection drug users were almost five and a half times more than non-IDUs at risk of HEV infection (P = 0.053). There was no significant association between seroprevalence of hepatitis E virus and education level (P = 0.46), duration of injection (P = 0.38) and location (P = 0.19).

Conclusions: Seroprevalence of hepatitis E virus among IDUs group was higher than non-IDU group, which might be due to possible blood transmission of HEV among IDUs.

Keywords: Injection, Drug Users, Hepatitis E Virus, Seroprevalence
Copyright © 2014, Hamadan University of Medical Sciences; Published by Safnek. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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