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Submitted: 19 Jul 2014
Revision: 26 Aug 2014
Accepted: 23 Sep 2014
ePublished: 12 Oct 2014
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Avicenna J Clin Microbiol Infect. 2014;1(3): 22165.
doi: 10.17795/ajcmi-22165
  Abstract View: 278
  PDF Download: 162

Research Article

The Association Between Chlamydia pneumoniae Infection and Ischemic Stroke

Peyman Eini 1, Fariba Keramat 1 * , Nasim Farajpoor 2

1 Department of Infectious Diseases, Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
2 School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
Corresponding author: Fariba Keramat, Department of Infectious Diseases, Brucellosis Research Center, Hamadan University of Medical Sciences, P. O. BOX: 65168, Hamadan, IR Iran. Tel: +98-9181113281, Fax: +98-8138269808 faribakeramat@yahoo.com

Abstract

Background: Chlamydia pneumoniae has been linked with increased risk of cardiovascular diseases; however, data on stroke and cerebrovascular accidents are sparse.

Objectives: The aim of this study was to determine the association between C. pneumoniae infection and ischemic stroke.

Patients and Methods: In a case-control study, 141 patients, admitted with ischemic stroke, were compared with gender and age-matched control subjects (n = 141). Using an enzyme-linked immunosorbent assay kit, the presence of C. pneumoniae IgG and IgA in the patients’ sera was determined. The data were analyzed by SPSS software (version 15) and were compared between the two groups using T-test and chi square test.

Results: The mean ages of the case and control groups were 68.97 ± 12.29 and 66.95 ± 6.68 years old, respectively. The difference between these two groups was not statistically significant (P = 0.102). The seroprevalence of C. pneumoniae-specific IgG were 78.7% in the patients with stroke and 52.5% in the control group. The difference between the two groups was statistically significant (P = 0.0001). The seroprevalence of C. pneumoniae-specific IgA were 41.1% in the stroke and 15.6% in the control group. The difference between the two groups was statistically significant (P = 0.0001).

Conclusions: The results supported the hypothesis that serological evidence of C. pneumoniae infection may be associated with an increased risk of ischemic stroke and cerebrovascular accident.

Keywords: Chlamydia pneumoniae, Cerebrovascular Accident, Stroke
Copyright © 2014, Hamadan University of Medical Sciences; Published by Safnek. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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