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Submitted: 04 Nov 2016
Revised: 03 Mar 2017
Accepted: 16 Apr 2017
First published online: 07 May 2017
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Avicenna J Clin Microbiol Infect. 2017;4(3): e43623.
doi: 10.5812/ajcmi.43623
  Abstract View: 160
  PDF Download: 146

Brief Report

Treatment of Hepatitis C Virus Infection in the HIV- Infected Patients by Pegylated Interferon and Ribavirin in Tehran, Iran

Ali Pashaei Zanjani 1, Negin Esmaeilpour 2, Mehrnaz Rasoolinejad 3, Pardis Moradnejad 1, Mojtaba Hedayat Yaghoobi 4 *

1 Specialist of Infectious Diseases, Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, IR Iran
2 Associate Professor of Infectious Diseases, Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, IR Iran
3 Professor of Infectious Diseases, Department of Infectious Diseases, Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, IR Iran
4 Assistant Professor of Infectious Diseases, Department of Infectious Diseases, Alborz University of Medical Sciences, Karaj, IR Iran
Corresponding author: Mojtaba Hedayat Yaghoobi, Assistant Professor of Infectious Diseases, Department of Infectious Diseases, Alborz University of Medical Sciences, Karaj, IR Iran. Email: hyaghooby@razi.tums.ac.ir

Abstract

Background and Objectives: Considering reductions in AIDS-related mortalities following effective anti-retroviral treatments in HIV/AIDS patients, HCV-associated liver diseases have turned into a major concern for HIV/HCV co-infected patients. The present study aims at determining SVR rates in HIV/HCV co-infected patients under pegylated interferon and ribavirin treatment referring to Tehran Imam Khomeini hospital during 2010 - 2013.

Methods: In this descriptive cross-sectional study, all HIV/HCV co-infected patients under pegilated interferon and ribavirin treatment referring to Tehran Imam Khomeini Hospital during 2010 - 2013 entered the study. The variables include demographic information, genotype, liver involvement stage in biopsy, viral load levels prior to treatment, 4th, 12th, and 48th week as well as 6 months after treatment (sustained virologic response (SVR)), and CD4 count every 3 months.

Results: In the total of 28 male HIV/HCV co-infected patients of this study, 21.4% and 78.6% received peg IFN alfa- 2b, and pegIFN alfa2a, respectively. There were 17 genotype I (61%), 9 (32%) genotype III, and 2 (7%) genotype II among the patients. The overall SVR rate of the patients was 67.8%; it was 52.9% in genotype I and 72.7% in genotypes II and III. Despite the CD4 count decline during treatment, opportunistic infections were not observed in any of the patients.

Conclusions: SVR rates in this study are higher than studies conducted in other countries and this implies the possibility of a more favorable genetic trait in Iranian HCV patients responding to pegIFN and ribavirin. That is still the proper regimen due to high price of free interferon regimens in Iran.

Keywords: HIV Infection, AIDS, Hepatitis C, Interferon-Alfa
Copyright © 2017, Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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