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Submitted: 28 Nov 2016
Revision: 14 Mar 2017
Accepted: 16 Apr 2017
ePublished: 09 May 2017
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Avicenna J Clin Microbiol Infect. 2017;4(3): 42214.
doi: 10.5812/ajcmi.42214
  Abstract View: 428
  PDF Download: 217

Research Article

An Epidemiological Study on the Prevalence and Antibiotic Resistance Patterns of Bacteria Isolated from Urinary Tract Infections in Central Iran

Fahimeh Ghanbari 1 * , Farzad Khademi 2, Shirin Saberianpour 3, Mojtaba Shahin 4, Nafiseh Ghanbari 5, Kourosh Naderi 6, Tahereh Motalebi-Rad 6

1 Student Research Committee, School of Medicine, Shahid Saddoghi University of Medical Sciences, Yazd, IR Iran
2 Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
3 Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IR Iran
4 Department of Microbiology, School of Medicine, Ahvaz University of Medical Sciences, Ahvaz, IR Iran
5 Department of Biology, Science and Art University, Yazd, IR Iran
6 Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
Corresponding author: Fahimeh Ghanbari, Department of Genetic, School of Medicine, Shahid Saddoghi University of Medical Sciences, Yazd, IR Iran. Tel: +98-9134347110 gh.fahimeh63@yahoo.com

Abstract

Background: Urinary tract infection (UTI) is one of the most common bacterial diseases in outpatients and inpatients worldwide. Treatment of UTI has become challenging due to the emergence of pathogens with increasing resistance to antimicrobial agents.

Objectives: The aim of this study was to determine the prevalence and antimicrobial resistance patterns of main bacteria responsible for UTI.

Methods: In this study, 326 patients with UTI, referring to Shahid Motahari hospital of Fuladshahr, Iran, were evaluated between March 2015 and February 2016. The isolated bacteria were identified by biochemical tests. Disk diffusion method was applied to determine the antibiotic sensitivity of bacterial agents.

Results: In a total of 326 positive urine cultures, 273 (83.74%) and 53 (16.25%) samples belonged to females and males, respectively. The most prevalent isolates were Escherichia coli(58.28%), Klebsiella spp. (11.65%), Staphylococcus spp. (11.65%), Enterobacter spp. (7.05%), Streptococcus spp. (3.68%), Enterococcus spp. (2.45%), Proteus spp. (1.22%), Pseudomonas spp. (0.61%), and Citrobacter spp. (0.61%), respectively. The antimicrobial susceptibility analysis of E. coli, as the predominant cause of UTI, revealed the following results: gentamicin (28.6%), ciprofloxacin (48.4%), nitrofurantoin (12.2%), nalidixic acid (63.7%), trimethoprim/sulfamethoxazole (67.9%), cephalothin (60%), cefotaxime (44.8%), imipenem (9.5%), amikacin (66.7%), and ampicillin (85.3%).

Conclusions: According to the present survey, E. coli isolates were the predominant pathogens in UTIs and were more prevalent in women than men. In the present study, the frequency of UTI pathogens was comparable to that reported in previous studies, showing an increasing resistance pattern to commonly prescribed antibiotics.

Keywords: Urinary Tract Infection, Antimicrobial resistance, E. coli
Copyright © 2017, Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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