Logo-ajcmi
Submitted: 06 Jun 2018
Accepted: 20 Nov 2018
First published online: 29 Dec 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

Avicenna J Clin Microbiol Infect. 2018;5(4):77-81.
doi: 10.15171/ajcmi.2018.16
  Abstract View: 73
  PDF Download: 88

Research Article

Diagnostic Value of Serum Adenosine Deaminase Level in Extrapulmonary Tuberculosis

Shokrollah Salmanzadeh 1 ORCID logo, Mahsa Soleimani 2, Mohammad Javad Mohammadi 3, Seyed Mohammad Alavi 1 * ORCID logo

1 Health Research Institute, Infectious and Tropical Disease Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Razi Teaching Hospital, Clinical Research Development Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Abadan School of Medical Sciences, Abadan, Iran
*Corresponding author: Seyed Mohammad Alavi, MD, Professor of Infectious Diseases, Health Research Institute, Infectious and Tropical Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Iran. Tel: +989161184916 Email: Email: alavi-sm@ajums.ac.ir

Abstract

Background: Although tuberculosis is a known disease, still on occasion, the tuberculosis patients remain undiagnosed and hence not treated appropriately. In some cases, the patient is not able to give a proper sputum sample. In some other cases, expert laboratory technician to examine the patient’s sputum smear is not available. Furthermore, and in most cases of extrapulmonary tuberculosis, invasive diagnostic procedures such as biopsy might be followed. The aim of this study was to investigate the diagnostic value of serum level of adenosine deaminase (ADA) in extra pulmonary tuberculosis.

Methods: In this analytical study, pulmonary tuberculosis patients were compared with two other groups of patients including lung cancer patients and healthy controls, based on national tuberculosis protocol. In each group, 40 patients who almost matched for age and sex were included. Blood samples were taken from the participants to measure serum ADA levels. Data were analyzed using SPSS software version 15.0.

Results: Based on the data analyzed in this study, the mean ADA level in the patients with extra pulmonary tuberculosis was 23.8 IU/L which was significantly higher than that in the other groups (P<0.001). Mean ADA levels in lung cancer patients and in healthy subjects were 15.8 IU/L and 10.7 IU/L, respectively.

Conclusions: According to the results of this study, higher cut-off value for ADA would increase the specificity up to 100%. Moreover, serum ADA level can be a valuable additional index in diagnosis of extra pulmonary tuberculosis.

Keywords: Pulmonary tuberculosis, Lung cancer, Adenosine deaminase
First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 73

Your browser does not support the canvas element.


PDF Downloaded: 88

Your browser does not support the canvas element.