Logo-ajcmi
Submitted: 06 Dec 2015
Revision: 25 Mar 2016
Accepted: 24 Sep 2016
ePublished: 17 Oct 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Avicenna J Clin Microbiol Infect. 2016;3(4): 35247.
doi: 10.17795/ajcmi-35247
  Abstract View: 1056
  PDF Download: 508

Research Article

Occult Hepatitis B in Patients Co-Infected With Hepatitis C and Human Immunodeficiency Viruses

Mohammad Mahdi Majzoobi 1, Seyyed Hamid Hashemi 1*, Hosein Mahjoob 2, Saeid Khakizadeh 3, Mina Nikbakht 4

1 Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Epidemiology and Statistics, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran
4 Consult Center for HIV, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Email: shahashemi@yahoo.com

Abstract

Objectives: Diagnosis of the occult hepatitis B virus (HBV) infection in patients co-infected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is important due to the fact that the HBV infection may have a clinical impact on liver disease in coinfected HIV/HCV patients. Isolated hepatitis B core antibody (HBcAb) positive HBV infection has been reported in HIV patients. The aim of this study was to determine the occult hepatitis B in patients co-infected with HCV-HIV.

Methods: In a cross-sectional study, hepatitis B surface antigen (HBsAg) and HBcAb tests were performed for all HIV-HCV co-infected patients, referred to the HIV Clinic of Hamadan. HBsAb was requested for HBsAg negative-HBcAb positive individuals and in the case of negative HBsAb, HBV-DNA PCR was performed. Finally the collected data was analyzed with SPSS.

Results: Of 103 HIV-HCV coinfected patients, both HBsAg and HBcAb were positive in 7 patients (6.8%), negative in 44 (42.7%) patients and 52 (50.5%) of all patients were HBsAg negative and HBcAb positive, which positivity of HBsAg had statistical correlation with positivity of HBcAb. In the last group HBsAb and HBV-DNA PCR were done, which resulted in the titer of antibody to be positive in 4 patients (7.7%) and the PCR to be negative in all (100%) patients.

Conclusions: The significant number of coinfected HIV-HCV patients only had HBcAb positive test without detectable HBV-DNA. Further studies for detection of HBV-DNA in both serum and liver biopsy specimens may help clarify the impact of HBV infection in coinfected HIV/HCV patients.


Copyright © 2016, Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1057

Your browser does not support the canvas element.


PDF Download: 508

Your browser does not support the canvas element.