Submitted: 22 Aug 2014
Revised: 22 Oct 2014
Accepted: 09 Nov 2014
First published online: 20 Feb 2015
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Avicenna J Clin Microbiol Infect. 2015;2(1): e22982.
doi: 10.17795/ajcmi-22982
  Abstract View: 78
  PDF Download: 71

Research Article

Antibacterial Effects of Origanum vulgare Essence Against Multidrug-Resistant Acinetobacter baumannii Isolated From Selected Hospitals of Tehran, Iran

Hossein Saghi 1,2, Abbas Bahador 3, Azad Khaledi 3, Ramazanali Ataee Kachoei 4, Ferdoes Amiri Dastjerdi 1, Davoud Esmaeili 2 *

1 AJA University of Medical Sciences, Tehran, IR Iran
2 Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
3 Department of Microbiology, Tehran University of Medical Sciences, Tehran, IR IranDepartment of Microbiology, Tehran University of Medical Sciences, Tehran, IR Iran
4 Department of Microbiology, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Corresponding author: Davoud Esmaeili, Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran. Tel: +98-9124395884, Fax: +98-2177601533, Email: esm114@gmail.com

Article

Background: Infection due to Acinetobacter baumannii has become a significant challenge to modern healthcare systems. The rapid emergence and global dissemination of A. baumannii as a major nosocomial pathogen is remarkable and it demonstrates its successful adaptation to the 21st century hospital environment. Recent studies have discussed about essential oil of Origanum vulgare against a range of bacteria, including various species of Staphylococcus, Pseudomonas, Bacillus and Escherichia coli.

Objectives: The present study aimed to investigate the inhibitory effects O. vulgare essence against multidrug-resistant (MDR) strains of A. baumannii from selected hospitals in Tehran, Iran.

Materials and Methods: This oil was obtained using the hydrodistillation method and analyzed by gas chromatography mass spectrography (GC/MS). The antimicrobial activity against MDR isolates was achieved using disc diffusion method and macro-broth dilution assay.

Results: Analysis of the essential oil revealed the presence of pulegone (68.59%) piperitone (7.8%), piperitenone (7.8%), 1, 8-cineole (1.3%), and carvacrol (1.6%) as the major components. The results showed a significant activity against MDR A. baumannii with inhibition zones and minimal inhibitory concentration values in the ranges of 7-15 mm and 20-35 µL/mL respectively.

Conclusions: This investigation showed that the essence oil of O. vulgare had a potent antimicrobial activity against MDR A. baumannii. Further research is required to evaluate the practical values of therapeutic applications.

Copyright © 2015, Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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