Submitted: 12 Aug 2017
Revised: 27 Dec 2017
Accepted: 07 Jan 2018
First published online: 25 Feb 2018
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Avicenna J Clin Microbiol Infect. 2018;5(1): e60088.
doi: 10.5812/ajcmi.60088
  Abstract View: 79
  PDF Download: 68

Research Article

The Prevalence of Panton-Valentine Lukocidin Gene in Staphylococcus aureus Species Isolated From Nosocomial Infections in Isfahan, Iran

Fahimeh Nourbakhsh 1 * ORCiD, Samaneh Borooni 2, Elaheh Tajbakhsh 3

1 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Nourdanesh Institute of Higher Education of Meymeh, Esfahan, IR Iran
3 Associated Professor, Department of Microbiology, Islamic Azad University, Shahrekord Branch, Shahrekord, IR Iran
Corresponding author: Fahimeh Nourbakhsh, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran. Email: nourbakhshf951@mums.ac.ir

Article

Background: Staphylococcus aureus is a significant pathogen and major cause of nosocomial and community-acquired infections. The current study aimed at investigating the frequency of Panton-Valentine leukocidin (PVL) gene as a serious virulence factor causing WBC destruction.

Methods: Collectively, 100 species of S. aureus were isolated from Isfahan, Iran, hospitals and confirmed by biochemical tests (coagulase, mannitol fermentation, and DNase). The antibiotic resistance patterns were studied by the disk diffusion method.

Results: Out of the 100 isolates, 56.2% were PVL positive of which 19.8% from abscess, 51.7% from wound, 23.2% from bedsore, and 5.3% from tracheal secretion. Among the detected isolates, 87.8% were resistant to methicillin.

Conclusions: The current study showed the high frequency of PVL in wound strains. Further studies are required to understand the distribution of these virulent isolates in order to decrease the risk of infection. High quality hospital cares as well as new antibiotics is required to combat the multidrug resistant bacteria.

Copyright © 2018, Avicenna Journal of Clinical Microbiology and Infection. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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